Double‐stranded RNA induces S100 gene expression by a cycloheximide‐sensitive factor | Zendy

Voss Andreas | Zendy; Gescher Kirsten | Zendy; Hensel Andreas | Zendy; Nacken Wolfgang | Zendy; Zänker Kurt S. | Zendy; Kerkhoff Claus | Zendy

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Double‐stranded RNA induces S100 gene expression by a cycloheximide‐sensitive factor

Author(s) -

Voss Andreas,

Gescher Kirsten,

Hensel Andreas,

Nacken Wolfgang,

Zänker Kurt S.,

Kerkhoff Claus

Publication year - 2012

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2011.12.022

Subject(s) - s100a9 , cycloheximide , gene expression , biology , rna silencing , gene , rna , s100a8 , brefeldin a , microbiology and biotechnology , interferon , rna interference , cell , immunology , protein biosynthesis , biochemistry , golgi apparatus

Viral double‐stranded RNA (dsRNA) and its synthetic analog polyI:C are recognized via multiple pathways and induce the expression of genes related to inflammation. In the present study, we demonstrated the polyI:C‐induced gene expression of the damage associated molecular pattern (DAMP) molecules S100A8 and S100A9, while other S100 genes were not affected. Cycloheximide and Brefeldin A treatment revealed both the expression of S100A8 and S100A9 as secondary response genes and the involvement of polyI:C‐induced cytokines herein. Several type I and type III interferons such as IFNβ, IL‐20, IL‐24, and IFNλ/IL‐29 were expressed in response to polyI:C, however, they failed to induce S100A8 and S100A9 gene expression. These data indicate the involvement of the danger molecule S100A8/A9 in the resistance against viruses.

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