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The yeast metacaspase is implicated in oxidative stress response in frataxin‐deficient cells
Author(s) -
Lefevre Sophie,
Sliwa Dominika,
Auchère Françoise,
Brossas Caroline,
Ruckenstuhl Christoph,
Boggetto Nicole,
Lesuisse Emmanuel,
Madeo Frank,
Camadro Jean-Michel,
Santos Renata
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.12.002
Subject(s) - frataxin , heme , oxidative stress , biochemistry , mitochondrion , superoxide , biology , reactive oxygen species , mitochondrial ros , superoxide dismutase , chemistry , enzyme , aconitase
Friedreich ataxia is the most common recessive neurodegenerative disease and is caused by reduced expression of mitochondrial frataxin. Frataxin depletion causes impairment in iron–sulfur cluster and heme biosynthesis, disruption of iron homeostasis and hypersensitivity to oxidants. Currently no pharmacological treatment blocks disease progression, although antioxidant therapies proved to benefit patients. We show that sensitivity of yeast frataxin‐deficient cells to hydrogen peroxide is partially mediated by the metacaspase. Metacaspase deletion in frataxin‐deficient cells results in recovery of antioxidant capacity and heme synthesis. In addition, our results suggest that metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability.