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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
Author(s) -
Simón Diana,
García-García Esther,
Royo Felix,
Falcón-Pérez Juan Manuel,
Avila Jesús
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.11.022
Subject(s) - proteostasis , intracellular , secretion , vesicle , microbiology and biotechnology , extracellular , chemistry , tau protein , membrane , extracellular vesicles , biophysics , biochemistry , biology , medicine , alzheimer's disease , disease
Increasing amounts of tau protein were expressed in non‐neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.