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Tristetraprolin down‐regulates IL‐17 through mRNA destabilization
Author(s) -
Lee Hyun Hee,
Yoon Nal Ae,
Vo Mai-Tram,
Kim Chae Won,
Woo Je Moon,
Cha Hee Jeong,
Cho Young Woo,
Lee Byung Ju,
Cho Wha Ja,
Park Jeong Woo
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.11.021
Subject(s) - tristetraprolin , messenger rna , chemistry , microbiology and biotechnology , biology , biochemistry , rna binding protein , gene
An excess of interleukin 17 (IL‐17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL‐17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL‐17 production in human T cell lines. Overexpression of TTP decreased the expression of IL‐17. Conversely, TTP inhibition by siRNA increased IL‐17 production. IL‐17 mRNA contains eight AREs within its 3′UTR. TTP bound directly to the IL‐17 mRNA 3′UTR at a location between the fourth and seventh AREs and enhanced decay of IL‐17 transcripts. These results suggest that TTP could control IL‐17‐mediated inflammation.