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Human immunodeficiency virus‐1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5′‐untranslated region
Author(s) -
Qu Jing,
Yang Zhenhua,
Zhang Qi,
Liu Weiyong,
Li Youxing,
Ding Qiong,
Liu Fang,
Liu Yingle,
Pan Zishu,
He Biao,
Zhu Ying,
Wu Jianguo
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.11.008
Subject(s) - hepatitis c virus , virology , untranslated region , internal ribosome entry site , five prime untranslated region , three prime untranslated region , biology , coinfection , ns2 3 protease , gene , virus , gene expression , translation (biology) , messenger rna , genetics
Coinfection with human immunodeficiency virus‐1 (HIV‐1) and hepatitis C virus (HCV) accelerates hepatitis C disease progression; however, the mechanism underlying this effect is unknown. Here, we investigated the role of HIV‐1 in HCV gene expression and the mechanism involved in this regulation. We discovered that HIV‐1 Rev protein activates HCV gene expression. We further revealed that Rev binds to the internal loop of the HCV 5′‐untranslated region (5′‐UTR) to stimulate HCV IRES‐mediated translation.