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Following G‐quadruplex formation by its intrinsic fluorescence
Author(s) -
Dao Nguyen Thuan,
Haselsberger Reinhard,
Michel-Beyerle Maria-Elisabeth,
Phan Anh Tuân
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.11.004
Subject(s) - g quadruplex , fluorescence , folding (dsp implementation) , chemistry , biophysics , dna , biology , biochemistry , physics , quantum mechanics , electrical engineering , engineering
We characterized and compared the fluorescence properties of various well‐defined G‐quadruplex structures. The increase of intrinsic fluorescence of G‐rich DNA sequences when they form G‐quadruplexes can be used to monitor the folding and unfolding of G‐quadruplexes as a function of cations and temperature. The temperature‐dependent fluorescence spectra of different G‐quadruplexes also exhibit characteristic patterns. Thus, the stability and possibly also the structure of G‐quadruplexes can be characterized and distinguished by their intrinsic fluorescence spectra.