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Silencing of miR‐124 induces neuroblastoma SK‐N‐SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR
Author(s) -
Huang Tsui-Chin,
Chang Hsin-Yi,
Chen Cheng-Yu,
Wu Pei-Yi,
Lee Hsinyu,
Liao Yung-Feng,
Hsu Wen-Ming,
Huang Hsuan-Cheng,
Juan Hsueh-Fen
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.10.025
Subject(s) - neuroblastoma , cell cycle checkpoint , gene silencing , cell cycle , gene knockdown , cancer research , microrna , apoptosis , microbiology and biotechnology , aryl hydrocarbon receptor , cell growth , biology , cellular differentiation , chemistry , cell culture , transcription factor , genetics , gene
Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR‐124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR‐124 promotes neuroblastoma SK‐N‐SH cell differentiation, cell cycle arrest and apoptosis. Further miR‐124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR‐124 may suppress the expression of AHR by targeting its 3′‐UTR. These results suggest that miR‐124 could serve as a potential therapeutic target of neuroblastoma.