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Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB
Author(s) -
Trevisan Glauce L.,
Oliveira Ernna H.D.,
Peres Nalu T.A.,
Cruz Aline H.S.,
Martinez-Rossi Nilce M.,
Rossi Antonio
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.09.037
Subject(s) - aspergillus nidulans , rna splicing , signal transduction , transcription factor , alternative splicing , transcription (linguistics) , gene , microbiology and biotechnology , chemistry , rna , metabolic pathway , biology , biochemistry , messenger rna , linguistics , philosophy , mutant
Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes. This adaptive response involves the conserved PacC/Pal signal transduction pathway, which mediates the transcriptional response to ambient pH. In this study, we show that transcription of the gene for PacC is modulated in response to nutrient changes, phosphate and carbon sources, and pH. In addition, we show that transcription of pacC is modulated in response to alternative RNA splicing of the palB gene. These results reveal novel aspects of the complex network involved in modulation of pacC .