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Protein kinase C‐theta in platelet activation
Author(s) -
Cohen Sagit,
Braiman Alex,
Shubinsky George,
Isakov Noah
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.09.014
Subject(s) - gpvi , protein kinase c , microbiology and biotechnology , signal transduction , platelet activation , integrin , platelet , kinase , protein kinase a , hemostasis , receptor , platelet glycoprotein gpiib iiia complex , protease activated receptor , chemistry , clot retraction , biology , biochemistry , thrombin , immunology , medicine
Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease‐activated receptor (PAR)‐, glycoprotein VI (GPVI) receptor‐ and glycoprotein α IIb β 3 integrin receptor‐linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.