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Linalool reduces the expression of 3‐hydroxy‐3‐methylglutaryl CoA reductase via sterol regulatory element binding protein‐2‐ and ubiquitin‐dependent mechanisms
Author(s) -
Cho Sung-Yun,
Jun Hee-jin,
Lee Ji Hae,
Jia Yaoyao,
Kim Kyoung Heon,
Lee Sung-Joon
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.09.012
Subject(s) - chromatin immunoprecipitation , reductase , sterol regulatory element binding protein , linalool , biochemistry , hmg coa reductase , gene expression , ubiquitin , chemistry , proteolysis , coenzyme a , biology , enzyme , gene , promoter , food science , essential oil
We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti‐oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6 weeks significantly lowered total and low‐density lipoprotein cholesterol concentrations, and HMG‐CoA reductase protein expression (−46%; P < 0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG‐CoA reductase by reducing the binding of SREBP‐2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin‐dependent proteolysis of the HMG‐CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms.