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MiR‐483‐5p controls angiogenesis in vitro and targets serum response factor
Author(s) -
Qiao Yu,
Ma Ning,
Wang Xidi,
Hui Yang,
Li Fuyuan,
Xiang Ying,
Zhou Jianying,
Zou Chaoxia,
Jin Jianfeng,
Lv Guixiang,
Jin Hongbo,
Gao Xu
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.08.039
Subject(s) - angiogenesis , microrna , biology , cancer research , growth factor , endogeny , gene , transcription factor , microbiology and biotechnology , bioinformatics , genetics , endocrinology , receptor
Angiogenesis, a key factor in ischemic heart disease, is rapidly initiated in response to hypoxic or ischemic conditions. MicroRNAs (miRNAs) are endogenously expressed small non‐coding RNAs that regulate gene expression at post‐transcriptional level. The recent discovery of the involvement of these RNAs in the control of angiogenesis renders them very attractive in the development of new approaches for restoring the angiogenic balance. In the present study, we explored that miR‐483‐5p, a microRNA embedded in the intron of insulin‐like growth factor 2 ( Igf2 ), acts as an endogenous angiogenesis‐inhibiting factor. We identified that serum response factor (SRF) is one of miR‐483‐5p target genes. These findings indicated that the miR‐483‐5p‐SRF pathway may offer a novel strategy for treatment with angiogenesis in ischemic heart disease patients.