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Regulatory T‐cells in systemic lupus erythematosus and rheumatoid arthritis
Author(s) -
Chavele Konstantia-Maria,
Ehrenstein Michael R.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.07.043
Subject(s) - rheumatoid arthritis , immunology , medicine , pathogenesis , phenotype , inflammation , autoimmunity , arthritis , systemic lupus erythematosus , effector , immune system , disease , biology , gene , genetics
Regulatory T‐cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA.