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Adipokine ganglioside GM2 activator protein stimulates insulin secretion
Author(s) -
Higashi Kiyoshi,
Kubo Hideki,
Watanabe Hiroyuki,
Fujimori Ko,
Mikami Toshiyuki,
Kaneko Hideo
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.07.012
Subject(s) - adipokine , medicine , endocrinology , insulin , leptin , secretion , stimulation , activator (genetics) , insulinoma , carbohydrate metabolism , chemistry , biology , receptor , obesity , insulin resistance
Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction. The aim of this study was to examine the impact of GM2AP on glucose metabolism in vivo. Injection of recombinant GM2AP in mice significantly lowered blood glucose levels in glucose tolerance tests. Administration of GM2AP to mice for 10 days increased serum insulin levels, whereas the contents of glucose, leptin and FFA were significantly decreased. Stimulation of calcium influx and insulin secretion by GM2AP was observed in hamster insulinoma HIT‐T15 cells. Blockage of GM2AP function by specific antibodies inhibited GM2AP‐induced insulin secretion. These results provide novel insights into the physiological functions of GM2AP in obesity.