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Bacillus subtilis MazF‐bs (EndoA) is a UACAU‐specific mRNA interferase
Author(s) -
Park Jung-Ho,
Yamaguchi Yoshihiro,
Inouye Masayori
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.07.008
Subject(s) - bacillus subtilis , escherichia coli , cleavage (geology) , messenger rna , biology , gene , bacteria , biochemistry , chemistry , microbiology and biotechnology , genetics , paleontology , fracture (geology)
MazF is an mRNA interferase which cleaves mRNAs at a specific sequence. Here, we show that in contrast to MazF‐ec from Escherichia coli , which specifically cleaves ACA sequences , MazF‐bs from Bacillus subtilis is an mRNA interferase that specifically cleaves a five‐base sequence, UACAU. MazF homologues widely prevailing in Gram‐positive bacteria were found to be highly homologous to MazF‐bs, suggesting that they may also have similar cleavage specificity. This cleavage site is over‐represented in the B. subtilis genes associated with biosynthesis of secondary metabolites, suggesting that MazF‐bs may be involved in the regulation of the production of secondary metabolites.