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Homotropic and heterotropic interactions in cytochromes c 3 from sulphate reducing bacteria
Author(s) -
Turner David L.,
Catarino Teresa
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.07.007
Subject(s) - chemistry , cytochrome , cytochrome c , cytochrome c oxidase , bacteria , stereochemistry , biochemistry , enzyme , biology , genetics , mitochondrion
This article reviews the contribution of António Xavier and his associates to the study of multihaem cytochromes. Detailed analysis of interactions between the charges of the haems and protonatable groups reveals that electrostatic effects may be outweighed by subtle changes in conformation. This helps us to understand how tetrahaem cytochromes c 3 work and also gives an insight into the mechanism of cytochrome c oxidase.