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Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti‐silencing
Author(s) -
Wan Yakun,
Chen Weiming,
Xing Jie,
Tan Jinyin,
Li Bing,
Chen Huiying,
Lin Zhanxian,
Chiang Jung-Hsien,
Ramsey Saleem
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.06.036
Subject(s) - histone h2a , histone code , histone deacetylase , histone methylation , histone methyltransferase , histone , microbiology and biotechnology , histone deacetylase 2 , histone deacetylase 5 , biology , trichostatin a , sap30 , histone h1 , genetics , dna methylation , nucleosome , gene expression , gene
The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae . Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1‐mediated telomere anti‐silencing. This study demonstrates that a mutual cross‐talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.