Regucalcin (RGN/SMP30) alters agonist‐ and thapsigargin‐induced cytosolic [Ca 2+ ] transients in cells by increasing SERCA Ca 2+ ATPase levels | Zendy

Lai Pei | Zendy; Yip Nga Chi | Zendy; Michelangeli Francesco | Zendy

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Regucalcin (RGN/SMP30) alters agonist‐ and thapsigargin‐induced cytosolic [Ca 2+ ] transients in cells by increasing SERCA Ca 2+ ATPase levels

Author(s) -

Lai Pei,

Yip Nga Chi,

Michelangeli Francesco

Publication year - 2011

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2011.05.058

Subject(s) - serca , thapsigargin , endoplasmic reticulum , microbiology and biotechnology , atpase , agonist , downregulation and upregulation , homeostasis , cytosol , biology , chemistry , biochemistry , enzyme , receptor , gene

Regucalcin (RGN), also reported as senescence marker protein‐30 (SMP30), plays a role in Ca 2+ homeostasis by modulating a number of Ca 2+ ‐dependent proteins. RGN also plays a cyto‐protective role and its decrease is linked to age‐related diseases and cell death. This study shows that RGN reduces agonist (histamine)‐induced Ca 2+ transients in RGN + transfected COS‐7 cells (RGN + ) and also increases their Ca 2+ storage capacity. These observations are explained by RGN + cells having increased mRNA and protein expression levels of sarco/endoplasmic reticulum Ca 2+ ‐ATPase (SERCA). Therefore down‐regulation of RGN expression may contribute to characteristics of age‐dependent Ca 2+ homeostasis dis‐regulation, by decreasing SERCA levels.

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