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The carbohydrate ligands on the host embryo mediate intercellular migration of the parasitic wasp embryo
Author(s) -
Takahashi-Nakaguchi Azusa,
Hiraoka Tsuyoshi,
Iwabuchi Kikuo
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.05.055
Subject(s) - embryo , biology , heterologous , microbiology and biotechnology , embryonic stem cell , embryogenesis , host (biology) , fucose , glycoprotein , genetics , gene
Invasive stage embryos of the parasitic wasp Copidosoma floridanum transmigrate through the epithelium of phylogenetically distant host embryos in a manner that is similar to mammalian leukocyte infiltration. Host embryonic cells appear to recognize the invading wasp embryo by components on the cell surface. We developed an in vitro wasp entry inhibition assay and found that C‐type lectins of the wasp embryo bound to N‐linked carbohydrate chains with fucose residues on the surface of host embryo. This is the first report showing a receptor–ligand interaction between heterologous multicellular organisms.