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Innate immune responses in central nervous system inflammation
Author(s) -
Finsen Bente,
Owens Trevor
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.05.030
Subject(s) - microglia , innate immune system , inflammation , central nervous system , immunology , biology , immune system , neuroinflammation , neuroscience , microbiology and biotechnology
In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood–brain barrier that include angiotensin II receptors on astrocytes and immunoregulatory mediators such as Type I interferons which regulate cellular traffic. Myeloid cells at the blood–brain barrier present antigen to T cells and influence cytokine effector function. Myelin‐specific T cells interact with microglia and promote differentiation of oligodendrocyte precursor cells in response to axonal injury. These innate responses offer potential targets for immunomodulatory therapy.