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Insight from genome‐wide association studies in rheumatoid arthritis and multiple sclerosis
Author(s) -
Suzuki Akari,
Kochi Yuta,
Okada Yukinari,
Yamamoto Kazuhiko
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.05.025
Subject(s) - genome wide association study , rheumatoid arthritis , multiple sclerosis , major histocompatibility complex , genetic association , genetics , gene , biology , genetic predisposition , autoimmune disease , immunology , medicine , single nucleotide polymorphism , genotype , antibody
Autoimmune diseases are caused by multiple genes and environmental effects. In addition, genetic contributions and the number of associated genes differ among different diseases and ethnic populations. Genome‐wide association studies (GWAS) on rheumatoid arthritis (RA) and multiple sclerosis (MS) show that these diseases share many genetic factors. Recently, in addition to the major histocompatibility complex (MHC) gene, other genetic loci have been found to be associated with the risk for autoimmune diseases. This review focuses on the search for genetic variants that influence the susceptibility to RA and MS as typical autoimmune diseases and discusses the future of GWAS.