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MicroRNAs in rheumatoid arthritis
Author(s) -
Ceribelli Angela,
Nahid Md A.,
Satoh Minoru,
Chan Edward K.L.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.05.020
Subject(s) - rheumatoid arthritis , pathogenesis , microrna , autoantibody , medicine , biomarker , rheumatoid factor , arthritis , autoimmune disease , disease , immunology , downregulation and upregulation , bioinformatics , gene , antibody , biology , genetics
Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti‐cyclic citrullinated peptide are useful tools for early diagnosis, monitoring disease activity, and predicting prognosis. Recently, many groups have focused their attention on the role of microRNAs in the pathogenesis of RA, as well as a potential biomarker to monitor RA. In fact, the expression of some microRNAs, such as miR‐146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches.