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Epigenetic codes of PPARγ in metabolic disease
Author(s) -
Sugii Shigeki,
Evans Ronald M.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.05.007
Subject(s) - nuclear receptor , epigenetics , epigenomics , adipogenesis , peroxisome proliferator activated receptor , histone , dna methylation , biology , receptor , biochemistry , transcription factor , gene expression , adipose tissue , gene
Peroxisome proliferator‐activated receptor gamma (PPARγ), a ligand‐regulated nuclear hormone receptor, plays critical roles in metabolism and adipogenesis. PPARγ ligands such as thiazolidinediones (TZDs) exert insulin sensitizing and anti‐inflammatory effects primarily through action on adipocytes, and are thus widely used to treat metabolic syndrome, especially type II diabetes. A number of PPARγ interacting partners have been identified, many of which are known epigenetic regulators, including enzymes for histone acetylation/deacetylation and histone methylation/demethylation. However, their functional roles in the PPARγ transcriptional pathway are not well defined. Recent advances in ChIP‐based and deep sequencing technology are revealing previously underappreciated epigenomic mechanisms and therapeutic potentials of this nuclear receptor pathway.