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The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability
Author(s) -
Stephan Anna K.,
Kliszczak Maciej,
Morrison Ciaran G.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.067
Subject(s) - cohesin , establishment of sister chromatid cohesion , ubiquitin ligase , dna repair , biology , microbiology and biotechnology , chromatin , genome instability , dna ligase , homologous recombination , homologous chromosome , genetics , ubiquitin , dna , dna damage , gene
There exist three highly‐conserved structural maintenance of chromosomes (Smc) complexes that ensure genome stability during eukaryotic cell division. There are the well‐characterized cohesin and condensin complexes and the third Smc complex, Smc5/6. Nse2/Mms21, a SUMO ligase, is a component of the Smc5/6 complex and recent data have indicated that Nse1 may function as a ubiquitin ligase. Smc5/6 regulates sister chromatid cohesion, homologous recombination and chromatin structure and conformation. This review examines the functions of Smc5/6 in DNA repair and the maintenance of genomic integrity and explores the roles of the associated SUMO and ubiquitin ligases. Recent findings have indicated that Smc5/6 may play a topological role in chromosome dynamics, which may help understand the complexity of its activities.