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MicroRNA regulation constrains the organization of target genes on mammalian chromosomes
Author(s) -
Wang Zhen-Zhen,
Gong Bin-Sheng,
Wang Hua-Kun,
Wang Hong-Jiu,
Zhou Meng,
Wang Qiang-Hu,
Chen Xi,
Liu Tao,
Li Xia
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.059
Subject(s) - microrna , gene , biology , computational biology , genetics , regulation of gene expression , genome
The regulation of microRNAs (miRNAs) is a complicated process requiring a large number of molecular events to be coordinated in both space and time. It is not known whether this complicated regulation process constrains the organization of target genes on mammalian chromosomes. We performed a genome‐wide analysis to provide a better picture of chromosomal organization of miRNA target genes. Our results showed clustering of the target genes (TGs) of miRNAs on mammalian chromosomes, and further revealed that the particular gene organization is constrained by miRNA regulation. The clustering pattern of TGs provides an insight into the complexity of miRNA regulation.