Strategies for bypassing the membrane barrier in multidrug resistant Gram‐negative bacteria | Zendy

Bolla Jean-Michel | Zendy; Alibert-Franco Sandrine | Zendy; Handzlik Jadwiga | Zendy; Chevalier Jacqueline | Zendy; Mahamoud Abdallah | Zendy; Boyer Gérard | Zendy; Kieć-Koowicz Katarzyna | Zendy; Pagès Jean-Marie | Zendy

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Strategies for bypassing the membrane barrier in multidrug resistant Gram‐negative bacteria

Author(s) -

Bolla Jean-Michel,

Alibert-Franco Sandrine,

Handzlik Jadwiga,

Chevalier Jacqueline,

Mahamoud Abdallah,

Boyer Gérard,

Kieć-Koowicz Katarzyna,

Pagès Jean-Marie

Publication year - 2011

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2011.04.054

Subject(s) - efflux , bacteria , gram negative bacteria , microbiology and biotechnology , antibiotics , multiple drug resistance , intracellular , membrane permeability , bacterial outer membrane , biology , chemistry , membrane , biochemistry , escherichia coli , genetics , gene

Regarding bacterial susceptibility towards antibacterial agents, membrane permeability is part of the early bacterial defense. The bacterium manages the translocation process, influx and efflux, to control the intracellular concentration of various molecules. Antibiotics and biocides are substrates of these mechanisms and the continuing emergence of multidrug resistant isolates is a growing worldwide health concern. Different strategies could be proposed to bypass the bacterial membrane barrier, comprising influx and efflux mechanisms, in order to restore the activity of antibiotics against resistant bacteria.

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