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Strategies for bypassing the membrane barrier in multidrug resistant Gram‐negative bacteria
Author(s) -
Bolla Jean-Michel,
Alibert-Franco Sandrine,
Handzlik Jadwiga,
Chevalier Jacqueline,
Mahamoud Abdallah,
Boyer Gérard,
Kieć-Koowicz Katarzyna,
Pagès Jean-Marie
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.054
Subject(s) - efflux , bacteria , gram negative bacteria , microbiology and biotechnology , bacterial outer membrane , intracellular , membrane permeability , bacterial cell structure , multiple drug resistance , antibiotics , biology , chemistry , membrane , biochemistry , escherichia coli , genetics , gene
Regarding bacterial susceptibility towards antibacterial agents, membrane permeability is part of the early bacterial defense. The bacterium manages the translocation process, influx and efflux, to control the intracellular concentration of various molecules. Antibiotics and biocides are substrates of these mechanisms and the continuing emergence of multidrug resistant isolates is a growing worldwide health concern. Different strategies could be proposed to bypass the bacterial membrane barrier, comprising influx and efflux mechanisms, in order to restore the activity of antibiotics against resistant bacteria.