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Intracellular and intercellular processes determine robustness of the circadian clock
Author(s) -
Hogenesch John B.,
Herzog Erik D.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.048
Subject(s) - circadian clock , intracellular , circadian rhythm , biology , robustness (evolution) , microbiology and biotechnology , signal transduction , biological clock , bacterial circadian rhythms , mechanism (biology) , neuroscience , gene , genetics , philosophy , epistemology
Circadian clocks are present in most organisms and provide an adaptive mechanism to coordinate physiology and behavior with predictable changes in the environment. Genetic, biochemical, and cellular experiments have identified more than a dozen component genes and a signal transduction pathway that support cell‐autonomous, circadian clock function. One of the hallmarks of biological clocks is their ability to reset to relevant stimuli while ignoring most others. We review recent results showing intracellular and intercellular mechanisms that convey this robust timekeeping to a variety of circadian cell types.