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Roles of sequential ubiquitination of PCNA in DNA‐damage tolerance
Author(s) -
Zhang Weiwei,
Qin Zhoushuai,
Zhang Xiaojie,
Xiao Wei
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.044
Subject(s) - proliferating cell nuclear antigen , ubiquitin , dna damage , dna , dna repair , microbiology and biotechnology , chemistry , computational biology , genetics , biophysics , biology , biochemistry , gene
Living organisms not only repair DNA damage induced by environmental agents and endogenous cellular metabolites, but have also developed mechanisms to survive in the presence of otherwise lethal lesions. DNA‐damage tolerance (DDT) is considered such a mechanism that resumes DNA synthesis in the presence of replication‐blocking lesions. Recent studies revealed that DDT in budding yeast is achieved through sequential ubiquitination of DNA polymerase processivity factor, proliferating cell nuclear antigen (PCNA). It is generally believed that monoubiquitinated PCNA promotes translesion DNA synthesis, whereas polyubiquitinated PCNA mediates an error‐free mode of lesion bypass. This review will discuss how ubiquitinated PCNA modulates different means of lesion bypass.