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FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells
Author(s) -
Chen Simin,
Gai Junfang,
Wang Yeyu,
Li Hao
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.024
Subject(s) - downregulation and upregulation , microbiology and biotechnology , stromal cell , endothelial stem cell , hypoxia (environmental) , cell culture , transcription (linguistics) , chemistry , biology , cancer research , gene , biochemistry , in vitro , genetics , linguistics , philosophy , organic chemistry , oxygen
DEPP was initially cloned from the human endometrial stromal cell cDNA library, but the transcriptional regulation of DEPP remains largely unknown. We demonstrate here that expression of DEPP is FoxO‐dependent in human endothelial cells. Two functional FoxO‐responsive elements are identified in the DEPP promoter. Hypoxia stimulates DEPP expression in the endothelial cell line EA.hy926. Hypoxia‐induced upregulation of DEPP is dependent on FoxO expression. We conclude that DEPP is regulated at the level of transcription by FoxO in human vascular endothelial cells.