Premium
Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells
Author(s) -
Salim Samina,
Asghar Mohammad,
Taneja Manish,
Hovatta Iiris,
Wu Yuh-Lin,
Saha Kaustuv,
Sarraj Nada,
Hite Brian
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.023
Subject(s) - rgs2 , oxidative stress , microbiology and biotechnology , antioxidant , regulator , protein kinase a , chemistry , signal transduction , biology , g protein , kinase , biochemistry , gene , gtpase activating protein
Regulator of G‐protein signaling protein (RGS)‐2 is a modulator of anxiety and dysregulation of oxidative stress is implicated in anxiety. Also, RGS2 expression is reported to be induced by oxidative stress. Thus, if oxidative stress induces RGS2 expression and lack of RGS2 causes anxiety, then mechanisms that link RGS2 and oxidative stress potentially critical to anxiety must be revealed. Our study is the first to suggest role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase‐1 and glutathione reductase‐1 via activation of p38 MAPK and PKC pathways in an Sp‐1 dependent manner.