Zinc binding to human lactogenic hormones and the human prolactin receptor | Zendy

Voorhees Jeffrey L. | Zendy; Rao Geeta Vittal | Zendy; Gordon Timothy J. | Zendy; Brooks Charles L. | Zendy

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Zinc binding to human lactogenic hormones and the human prolactin receptor

Author(s) -

Voorhees Jeffrey L.,

Rao Geeta Vittal,

Gordon Timothy J.,

Brooks Charles L.

Publication year - 2011

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2011.04.019

Subject(s) - prolactin , prolactin receptor , hormone , zinc , receptor , chemistry , endocrinology , medicine , biology , biochemistry , organic chemistry

Zinc half sites are present in all human lactogenic hormones: human prolactin (hPRL), growth hormone (hGH), placental lactogens (hPL) and the hPRL receptor (hPRLr). The influence of divalent zinc (Zn 2+ ) as measured by intrinsic fluorescence or FRET in each of these hormones is unique and is affected by the presence of varying stoichiometries of hPRLr. These data show that both Zn 2+ and hPRLr binding influence hPRL conformers in an interdependent fashion. Although each of these three lactogenic hormones bind hPRLr and induce a biological response that is sensitive to the presence of increasing concentrations of Zn 2+ , each hormone is unique in the mechanistic details of this process.

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