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PANDER KO mice on high‐fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia
Author(s) -
Robert-Cooperman Claudia E.,
Wilson Camella G.,
Burkhardt Brant R.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.005
Subject(s) - medicine , hyperinsulinemia , endocrinology , glycemic , insulin , knockout mouse , intermittent fasting , insulin resistance , receptor
The recent creation of the PANDER (pancreatic‐derived factor) knockout (PANKO) and acute mouse models have revealed a biological function in the regulation of glycemic levels via promotion of hepatic glucose production (HGP) and pancreatic β‐cell insulin secretion. Therefore, we hypothesized that the absence of PANDER may afford some degree of protection from high‐fat diet (HFD) induced fasting hyperglycemia. On HFD, fasting glycemic levels were significantly lower in the PANKO mice. Also, fasting insulin levels and the in vivo insulin response following glucose injection were inhibited in PANKO mice. The lowered fasting glycemic levels are attributed to decreased HGP due to the absence of PANDER. Overall, our findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.