Premium
SUMOylation and de‐SUMOylation in response to DNA damage
Author(s) -
Dou Hong,
Huang Chao,
Van Nguyen Thang,
Lu Long-Sheng,
Yeh Edward T.H.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.002
Subject(s) - sumo protein , dna damage , dna repair , homologous recombination , ubiquitin , microbiology and biotechnology , sumo enzymes , genome instability , dna , biology , dna damage repair , rad51 , chemistry , genetics , gene
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin‐like modifier) can regulate protein stability, protein cellular location, and protein–protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de‐SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).