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Virus‐induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production
Author(s) -
Ng Sinnie Sin Man,
Chang Tsung-Hsien,
Tailor Prafullakumar,
Ozato Keiko,
Kino Tomoshige
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.04.001
Subject(s) - interferon regulatory factors , transactivation , irf3 , biology , nuclear receptor , irf8 , irf1 , interferon , messenger rna , liver x receptor , virology , microbiology and biotechnology , receptor , gene expression , transcription factor , gene , innate immune system , biochemistry
We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow‐derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3‐ or IRF7‐induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll‐like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC‐organizing anti‐viral response wherein NOR1 and LXRα participate in regulating interferon production.