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Control of nuclear receptor activities in metabolism by post‐translational modifications
Author(s) -
Berrabah Wahiba,
Aumercier Pierrette,
Lefebvre Philippe,
Staels Bart
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.03.066
Subject(s) - phosphorylation , nuclear receptor , mechanism (biology) , organism , microbiology and biotechnology , receptor , endogeny , transcriptional regulation , metabolism , biochemistry , transcriptional activity , biology , chemistry , computational biology , transcription factor , genetics , gene , epistemology , philosophy
Nuclear receptors (NRs) are molecular transducers of endocrine and dietary signals allowing tissues to adapt their transcriptional responses to endogenous or exogenous cues. These signals act in many cases as specific ligands, converting of NRs into transcriptionally active molecules. This on‐off mechanism needs, however, to be finely tuned with respect to the tissue environment and adjusted to the organism needs. These subtle adjustments of NR transcriptional activity are brought about by post‐translational modifications (PTMs), which can be, in the case of orphan NRs, the sole regulatory mechanism. The role of PTMs, with a more specific focus on phosphorylation, affecting the functions of NR controlling metabolic events is described in this review.