Premium
Cytokines and effector T cell subsets causing autoimmune CNS disease
Author(s) -
Petermann Franziska,
Korn Thomas
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.03.064
Subject(s) - effector , immunology , autoimmune disease , autoimmunity , disease , biology , microbiology and biotechnology , medicine , immune system , antibody , pathology
Although experimental autoimmune encephalomyelitis (EAE) is limited in its potency to reproduce the entirety of clinical and histopathologic features of multiple sclerosis (MS), this model has been successfully used to prove that MS like autoimmunity in the CNS is orchestrated by autoantigen specific T cells. EAE was also very useful to refute the idea that IFN‐γ producing T helper type 1 (Th1) cells were the sole players within the pathogenic T cell response. Rather, “new” T cell lineages such as IL‐17 producing Th17 cells or IL‐9 producing Th9 cells have been first discovered in the context of EAE. Here, we will summarize new concepts of early and late T cell plasticity and the cytokine network that shapes T helper cell responses and lesion development in CNS specific autoimmunity.