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Retrotransposons: Mobile and mutagenic from conception to death
Author(s) -
Faulkner Geoffrey J.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.03.061
Subject(s) - retrotransposon , biology , mobile genetic elements , human genome , genome , genetics , somatic cell , germline , transposition (logic) , computational biology , gene , transposable element , computer science , artificial intelligence
Mobile genetic elements feature prominently in mammalian genome evolution. Several transposition‐competent retrotransposon families (L1, Alu , SVA) remain active in the human germ line, leading to pathogenesis as well as genome structural variation across the global population. High‐throughput screening approaches have recently been developed to detect retrotransposon insertion polymorphisms. Evidence produced by these and other genome‐scale technologies indicates an expanded role for retrotransposition in human biology, including somatic mobilisation in the developing embryo and in neural cells.