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Phosphorylations: making the Neurospora crassa circadian clock tick
Author(s) -
Diernfellner A.C.R.,
Schafmeier T.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.03.049
Subject(s) - neurospora crassa , circadian clock , neurospora , circadian rhythm , biology , phosphorylation , bacterial circadian rhythms , microbiology and biotechnology , period (music) , oscillating gene , genetics , neuroscience , gene , mutant , acoustics , physics
Various post‐translational modifications have been identified that play a role in the function of circadian clocks. Among these, phosphorylation has been investigated extensively. It was shown that phosphorylation influences half‐life, subcellular localisation, transcriptional activity and conformation of clock components over the course of a circadian day. Recent observations also indicate that time‐of‐day specific sequential phosphorylation of the Neurospora crassa clock protein FREQUENCY is crucial for measuring time and thus for establishing a robust circadian rhythm. The circadian clock of Neurospora is one of the best‐investigated molecular clocks to date. In this review, we summarise the data on what is known so far about the role of phosphorylation of proteins involved in the Neurospora circadian clock.