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Diminished AMPK signaling response to fasting in thioredoxin‐interacting protein knockout mice
Author(s) -
Andres Allen M.,
Ratliff Eric P.,
Sachithanantham Sowbarnika,
Hui Simon T.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.03.042
Subject(s) - txnip , thioredoxin interacting protein , ampk , medicine , endocrinology , knockout mouse , oxidative phosphorylation , glycolysis , glycogen , amp activated protein kinase , glut4 , protein kinase a , thioredoxin reductase , chemistry , thioredoxin , soleus muscle , oxidative stress , biology , skeletal muscle , phosphorylation , biochemistry , metabolism , glucose transporter , insulin , receptor
Thioredoxin‐interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate‐activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip.