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Down‐regulation of miR‐23b may contribute to activation of the TGF‐β1/Smad3 signalling pathway during the termination stage of liver regeneration
Author(s) -
Yuan Bin,
Dong Ruiqi,
Shi Duo,
Zhou Yunheng,
Zhao Ying,
Miao Mingyong,
Jiao Binghua
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.02.031
Subject(s) - regeneration (biology) , liver regeneration , microrna , transforming growth factor , microbiology and biotechnology , biology , signal transduction , apoptosis , cell growth , cancer research , gene , genetics
MicroRNAs (miRNAs) are known to play important roles in liver regeneration, although the role of miRNAs associated with the termination of liver regeneration is not as well studied. Here we reported the down‐regulation of miR‐23b in the termination stage of liver regeneration in rats. In addition, Smad3 was identified as a target of miR‐23b during liver regeneration. Up‐regulation of miR‐23b promoted BRL‐3A cell proliferation and partially inhibited transforming growth factor (TGF)‐β1‐induced apoptosis. Furthermore, TGF‐β1 transcriptionally inhibited miR‐23b expression. We conclude that down‐regulation of miR‐23b may contribute to activation of the TGF‐β1/Smad3 signalling pathway during the termination stage of liver regeneration.