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The daily rhythm of mice
Author(s) -
Ripperger Jürgen A.,
Jud Corinne,
Albrecht Urs
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.02.027
Subject(s) - circadian rhythm , clockwork , circadian clock , biology , bacterial circadian rhythms , function (biology) , neuroscience , identification (biology) , rhythm , computational biology , microbiology and biotechnology , genetics , medicine , ecology , physics , astronomy
The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various diseases or syndromes. Thus, this model system is not only perfectly suited to pinpoint the components of the mammalian circadian clock, but also to unravel metabolic, physiological, and pathological processes linked to the circadian timing system.