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IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton
Author(s) -
Kim Hugh,
White Colin D.,
Sacks David B.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.01.041
Subject(s) - iqgap1 , cytoskeleton , actin cytoskeleton , biology , microbiology and biotechnology , actin , innate immune system , scaffold protein , virulence , immune system , signal transduction , cell , immunology , genetics , gene
Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens’ virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens.