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Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cells?
Author(s) -
Eendebak Robert J.A.H.,
Lucassen Paul J.,
Fitzsimons Carlos P.
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2011.01.039
Subject(s) - microrna , nuclear receptor , biology , microbiology and biotechnology , neural stem cell , stem cell , receptor , regulation of gene expression , cellular differentiation , gene expression , gene , neuroscience , genetics , transcription factor
In this mini‐review, we focus on regulatory loops between nuclear receptors and microRNAs, an emerging class of small RNA regulators of gene expression. Evidence supporting interactions between microRNAs and nuclear receptors in the regulation of gene expression networks is discussed in relation to its possible role in neural stem cell self renewal and differentiation. Furthermore, we discuss possible disturbances of the regulatory loops between microRNAs and nuclear receptors in human neurodegenerative disease. Finally, we discuss the possible use of nuclear receptors as pharmacological entry points to regulate neural stem cell self‐renewal and differentiation.