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Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance
Author(s) -
Turban Sophie,
Hajduch Eric
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.12.022
Subject(s) - diacylglycerol kinase , insulin resistance , protein kinase c , ceramide , gene isoform , insulin receptor , insulin , kinase , microbiology and biotechnology , signal transduction , lipid metabolism , protein kinase a , biology , chemistry , medicine , endocrinology , biochemistry , apoptosis , gene
The role of protein kinase C (PKCs) isoforms in the regulation of glucose metabolism by insulin is complex, partly due to the large PKC family consisting of three sub‐groups: conventional, novel and atypical. Activation of some conventional and novel PKCs in response to increased levels of diacylglycerol (DAG) have been shown to counteract insulin signalling. However, roles of atypical PKCs (aPKCs) remain poorly understood. aPKCs act as molecular switches by promoting or suppressing signalling pathways, in response to insulin or ceramides respectively. Understanding how DAG‐ and ceramide‐activated PKCs impair insulin signalling would help to develop treatments to fight insulin resistance.