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Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene
Author(s) -
Snyder Marylynn,
Huang Xin-Yun,
Zhang J. Jillian
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.11.030
Subject(s) - stat3 , microbiology and biotechnology , stat protein , gene expression , transcription factor , cellular differentiation , rna interference , activator (genetics) , biology , transcription (linguistics) , regulation of gene expression , gene , rna , signal transduction , genetics , linguistics , philosophy
The transcription factor Signal Transducer and Activator of Transcription 3 (Stat3) functions in various cellular processes including neuronal differentiation. We show that the SRY‐box containing gene 6 (Sox6) gene, important for neuronal differentiation, is a direct target gene of Stat3. We demonstrate that in response to ligand stimulation, Stat3 binds to the Sox6 promoter and induces its expression. Furthermore, Stat3 is activated and Sox6 is induced during neuronal differentiation of P19 cells in the absence of exogenous ligand treatment. Moreover, using an RNA interference approach, we show that Stat3 is required for Sox6 expression during neuronal differentiation.