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Helicobacter pylori chromosomal DNA replication: Current status and future perspectives
Author(s) -
Nitharwal Ram Gopal,
Verma Vijay,
Dasgupta Santanu,
Dhar Suman Kumar
Publication year - 2011
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.11.018
Subject(s) - helicobacter pylori , biology , dna replication , genetics , helicase , dna , microbiology and biotechnology , gene , rna
Helicobacter pylori causes gastritis, gastric ulcer and gastric cancer. Though DNA replication and its control are central to bacterial proliferation, pathogenesis, virulence and/or dormancy, our knowledge of DNA synthesis in slow growing pathogenic bacteria like H. pylori is still preliminary. Here, we review the current understanding of DNA replication, replication restart and recombinational repair in H. pylori . Several differences have been identified between the H. pylori and Escherichia coli replication machineries including the absence of DnaC, the helicase loader usually conserved in gram‐negative bacteria. These differences suggest different mechanisms of DNA replication at initiation and restart of stalled forks in H. pylori .