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Phylogenetic analysis and evolution of aromatic amino acid hydroxylase
Author(s) -
Cao Jun,
Shi Feng,
Liu Xiaoguang,
Huang Guang,
Zhou Min
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.11.005
Subject(s) - phylogenetic tree , intron , functional divergence , lineage (genetic) , biology , gene , exon , evolutionary biology , phylogenetics , molecular evolution , conserved sequence , genetics , sequence analysis , divergence (linguistics) , gene family , peptide sequence , genome , linguistics , philosophy
A study was performed to investigate the phylogenetic relationship among AAAH members and to statistically evaluate sequence conservation and functional divergence. In total, 161 genes were identified from 103 species. Phylogenetic analysis showed that well‐conserved subfamilies exist. Exon–intron structure analysis showed that the gene structures of AAAH were highly conserved across some different lineage species, while some species‐specific introns were also found. The dynamic distribution of ACT domain suggested one gene fusion event has occurred in eukaryota. Significant functional divergence was found between some subgroups. Analysis of the site‐specific profiles revealed critical amino acid residues for functional divergence. This study highlights the molecular evolution of this family and may provide a starting point for further experimental verifications.