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Understanding signal integration through targeted mutations of an adapter protein
Author(s) -
Zou Tao,
May Rebecca M.,
Koretzky Gary A.
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.10.025
Subject(s) - adapter (computing) , signal transducing adaptor protein , computational biology , signal transduction , biology , function (biology) , microbiology and biotechnology , chemistry , computer science , computer hardware
Immunoreceptor engagement leads to the activation of multiple second messenger cascades, and integration of these pathways requires proper function of a number of adapter proteins. Although adapters possess no intrinsic enzymatic function, they nucleate the formation of multi‐molecular protein complexes to support downstream signaling. Since adapters contain functionally distinct domains, intense investigation has been devoted to understanding how these regions act to integrate signals. This review describes the evolution of studies investigating one of these adapters, the SH2 domain‐containing leukocyte protein of 76 kDa. Through utilizing biochemical, genetic and imaging techniques, a model has emerged describing how this adapter regulates signals resulting in complex immune responses.