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A conserved gene cluster as a putative functional unit in insect innate immunity
Author(s) -
Somogyi Kálmán,
Sipos Botond,
Pénzes Zsolt,
Andó István
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.10.014
Subject(s) - innate immune system , biology , drosophila melanogaster , genome , gene cluster , gene , insect , genetics , cluster (spacecraft) , evolutionary biology , computational biology , immune system , ecology , computer science , programming language
The Nimrod gene superfamily is an important component of the innate immune response. The majority of its member genes are located in close proximity within the Drosophila melanogaster genome and they lie in a larger conserved cluster (“Nimrod cluster”), made up of non‐related groups (families, superfamilies) of genes. This cluster has been a part of the Arthropod genomes for about 300–350 million years. The available data suggest that the Nimrod cluster is a functional module of the insect innate immune response.