Premium
The small RNA expression profile of the developing murine urinary and reproductive systems
Author(s) -
Aguilar Ana Laura Gutierrez,
Piskol Robert,
Beitzinger Michaela,
Zhu Jia Yun,
Kruspe Dagmar,
Aszodi Attila,
Moser Markus,
Englert Christoph,
Meister Gunter
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.09.050
Subject(s) - microrna , argonaute , biology , gene expression , computational biology , regulation of gene expression , small rna , gene , gene silencing , rna , rna interference , genetics , microbiology and biotechnology
microRNAs (miRNAs) are small non‐coding RNAs with fundamental roles in the regulation of gene expression. miRNAs assemble with Argonaute (Ago) proteins to miRNA‐protein complexes (miRNPs), which interact with distinct binding sites on mRNAs and regulate gene expression. Specific miRNAs are key regulators of tissue and organ development and it has been shown in mammals that miRNAs are also involved in the pathogenesis of many diseases including cancer. Here, we have characterized the miRNA expression profile of the developing murine genitourinary system. Using a computational approach, we have identified several miRNAs that are specific for the analyzed tissues or the developmental stage. Our comprehensive miRNA expression atlas of the developing genitourinary system forms an invaluable basis for further functional in vivo studies.