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Posttranscriptional control of mitochondrial biogenesis: Spatio‐temporal regulation of the protein import process
Author(s) -
Devaux Frédéric,
Lelandais Gaëlle,
Garcia Mathilde,
Goussard Sébastien,
Jacq Claude
Publication year - 2010
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2010.09.030
Subject(s) - mitochondrial biogenesis , biogenesis , microbiology and biotechnology , translation (biology) , regulon , mitochondrion , biology , messenger rna , respiratory chain , regulation of gene expression , computational biology , gene , biochemistry
This review focuses on the posttranscriptional processes which govern mitochondrial biogenesis, with a special emphasis on the asymmetric localization–translation of nuclear‐encoded mRNAs as an important regulatory step of the protein import process. We review how spatio‐temporal mRNA regulons help to elicit timely, versatile, and coordinated intracellular processes to assemble mitochondrial structures. Our current knowledge on the mitochondrial import of respiratory chain assembly factors and the role of the ribonucleic acid (RNA) binding protein Puf3 are presented. A connection with the target of rapamycine signalling pathway may explain how respiratory chain assembly senses environmental conditions via the protein import machinery.